Artemin and Its Emerging Role in Pathogenesis of Systemic Tumors Besides Pancreatic Cancers

Artemin and Its Emerging Role in Pathogenesis of Systemic Tumors Besides Pancreatic Cancers

TO THE EDITOR: The recent article by Demir et al. (2012) in your esteemed journal provided for highly stimulating and interesting reading. Interestingly, over the past few years artemin has been identified as a significant player in the enhancement of oncogenicity of various other tumors besides pancreatic cancers. For instance, artemin enhances transcription of bcl2 – leading to it’s up regula...

Skp2 and Its Emerging Role in the Pathogenesis of Systemic Malignancies Besides Breast Carcinomas

The recent article by Wang et al. (2012a) was highly interesting. Interestingly, recent data suggests that Skp2 expression may play a significant role in the etio-pathogenesis of a number of systemic malignancies besides breast carcinomas. For instance, the expression of Skp2 in prostate cancers is decreased by androgens and is mediated via pathways that are dependent on p107 as well as pathway...

Role of MTHFR C677T polymorphism in systemic carcinogenesis, besides its role in the pathogenesis of colo-rectal carcinomas.

sMICA and its emerging role as a prognostic and diagnostic indicator in systemic malignancies besides hepatocellular carcinoma

I read the recent article by Li . [1] with great interest. Intriguingly, emerging evidence suggests that soluble major histocompatibility complex class I­related chain A (sMICA) may be an important diagnostic and prognostic marker in a number of systemic malignancies besides hepatocellular carcinoma. For instance, higher sMICA levels are seen in oral squamous cell carcinomas of high TNM stages ...

Emerging applications of argatroban in the management of systemic malignancies: potential benefits besides its primary role as an antithrombin agent.

Emerging Applications of Argatroban in the Management of Systemic Malignancies Potential Benefits Besides Its Primary Role as an Antithrombin Agent The recent article by Coppens et al provided for highly stimulating reading. Argatroban may exert several antineoplastic effects besides its antithrombin effects. Argatroban exerts significant antineoplastic effects in gliomas. Thrombin, in general,...